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KMID : 1131320140160020181
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Journal of Korean Society of Computed Tomographic Technology
2014 Volume.16 No. 2 p.181 ~ p.187
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Comparison of the contrast effect of the amount and iodine concentration of CT contrast agent
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Kim Yun-Ki
Kim Myeong-Seong
Le Su-Yeon
Lee Ji-Man
Lee Hyeong-Sun
Jeong Jong-Sung
Kim Myeong-Gu
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Abstract
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Purpose : Computed tomography contrast agent differs in the product name in accordance with the concentration of iodine. Examinations using contrast agent are selectively taken according to the situation such as a patient with high risk of contrast agent side effects and characteristics of the test. I tried to compare the difference of contrast enhancing effect depending on the amount and the iodine concentration of contrast agent.
Material and Methods : Using 64slice MDCT (GE Healthcare, Discovery 750HD, USA), I measured the Hounsfield Unit(HU) for people and phantom by the following method.
1) I injected the pure contrast and the diluted contrast(one-to-one mixture of saline and contrast media) separately by iodine concentration to the phantom(Alderson Rando Phantom). And I selected the specific resions to measur the HU of the image.
2) Using the contrast agents with different iodine concentration, I tested a man whose weight is 74kg for dynamic liver CT. And I obtained the images of 40 seconds after contrast agent injection.
3) Using the contrast agents with 300 iodine concentration, I tested 18 patients whose weight is ranging 47kg to 73kg for dynamic liver CT. And I obtained the images of 40 seconds after contrast agent injection.
HU is measured by PACS equipment(M-view5.4 Infinitt Healthcare PACS, Korea). I measured the region of interest in the superior mesenteric artery and abdominal aorta.
I analysed the data by using SPSS12 Korean version of Windows environment, and made linear regression analysis.
Result : There is no significant difference of Iodine-concentration HU in image between the pure contrast and diluted contrast using a phantom(p = 0.343, p = 0.287). There is no significant difference of HU in image using different Iodine-concentration for same person in both the superior mesenteric artery and abdominal aorta(p = 0.988, p = 0.443). There is a significant difference in abdominal aorta using the contrast agents with 300 iodine concentration(P = 0.045). But there is no significant difference in the superior mesenteric artery(P = 0.133).
Conclusion : There is no significant difference in Iodine-concentration but is significant difference corresponding to the weight inversely. This disproves the amount of contrast agent affects HU. Therefore, it is believed that the appropriate usage of lower concentration contrast agents than higher iodine concentration will be able to gain a greater contrast enhancement effect.
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KEYWORD
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Iodine concentration, Contrast agent, Hounsfield Unit(HU)
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